Home Neuronal Signaling Adrenergic Receptor antagonist Doxazosin For research use only.

Doxazosin

Synonyms: UK 33274

Doxazosin(UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

Doxazosin Chemical Structure

Doxazosin Chemical Structure

CAS No. 74191-85-8

Purity & Quality Control

Batch: S578201 DMSO]31 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.95%
99.95

Doxazosin Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Doxazosin(UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01946035 Completed
Allergic Rhinitis
University of Dundee
 September 2013 Phase 4
NCT01379898 Completed
Pheochromocytoma
University Medical Center Groningen|Radboud University Medical Center|UMC Utrecht|VU University of Amsterdam|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Leiden University Medical Center|Erasmus Medical Center|Maastricht University Medical Center|St. Antonius Hospital|Medisch Spectrum Twente|Maxima Medical Center|Canisius-Wilhelmina Hospital|Onze Lieve Vrouwe Gasthuis|Atrium Medical Center|Isala
 December 2011 Phase 4
NCT01062945 Completed
Cocaine Addiction|Cocaine Abuse|Cocaine Dependence|Substance Abuse
Baylor College of Medicine|National Institute on Drug Abuse (NIDA)
 January 2010 Phase 1
NCT00646841 Completed
Hypertension
Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer
 February 2003 Phase 4
NCT00645034 Completed
Benign Prostatic Hyperplasia
Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer
 November 2002 Phase 2

Chemical Information & Solubility

Molecular Weight 451.48 Formula

C23H25N5O5
CAS No. 74191-85-8 SDF --
Smiles COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 31 mg/mL ( (68.66 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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